1 Submission accepted 2 Approved # Partnered and/or in collaboration Registrational Phase II/III trial, Q2 2022 Oncology new molecular entity1 pipeline, AZD0171 + Imfinzi + CTx anti-LIF+PD-L1+CTx 1L metastatic pancreatic ductal adenocarcinoma, camizestrant + CDK4/6i SERENA-6 SERD+CDK4/6 1L HR+ HER2- ESR1m breast cancer, camizestrant + palbociclib SERENA-4 SERD+CDK4/6 1L HR+ HER2- breast cancer, AZD2936 ARTEMIDE-1# PD1/TIGIT bispecific mAb solid tumours, AZD7789 PD1/TIM3 bispecific mAb solid tumours, haem malignancies, AZD8701 +/- Imfinzi# FOXP3 +/- PD-L1 solid tumours, AZD4573 + Calquence CDK9+BTK haematological malignancies, Imfinzi (platform) COAST# PD-L1+multiple novel ONC therapies NSCLC, capivasertib + abiraterone CAPItello-281# AKT+abiraterone PTEN deficient mHSPC, capivasertib + docetaxel CAPItello-280# AKT inhibitor + docetaxel, capivasertib + fulvestrant CAPItello-291# AKT+fulvestrant locally-advanced (inoperable) or metastatic breast, capivasertib + CTx CAPItello-290# AKT+chemotherapy mTNBC 1L, capivasertib + fulvestrant + palbociclib CAPItello-292# AKT+fulvestrant+CDK4/6 HR+ breast 1L, datopotamab deruxtecan TROPION Lung08# TROP2 ADC 1L metastatic NSCLC, MEDI5752 + lenvatinib PD-1/CTLA-4+VEGF advanced renal cell carcinoma, TATTON# EGFR+MEK/MET advanced EGFRm NSCLC, Imfinzi (platform) HUDSON PD-L1+multiple novel ONC therapies post IO NSCLC, Imfinzi + Lynparza ORION# PD-L1+PARP1L mNSCLC, Imfinzi (platform) NeoCOAST# PD-L1+multiple novel ONC therapies NSCLC, Imfinzi + monalizumab# PD-L1+NKG2A solid tumours, oleclumab + CTx or Imfinzi + oleclumab + CTx CD73+chemo or PD-L1+CD73+chemo pancreatic, Tagrisso + Orpathys SAVANNAH# EGFR+MET advanced EGFRm, datopotamab deruxtecan TROPION-Breast01# TROP2 ADC 2-3L HR+ HER2- BC, datopotamab deruxtecan TROPION-Lung01# TROP2 ADC 2L+ NSCLC with and without actionable alterations, Imfinzi + tremelimumab + SoC NILE PD-L1+CTLA-4+SoC 1L urothelial cancer, Lynparza + Imfinzi + bevacizumab DUO-O#PARP+PD-L1+VEGF 1L ovarian, Imfinzi +- oleclumab +- mona unresectable stage III NSCLC PACIFIC-9#PD-L1+NKG2A or PD-L1+CD73 NSCLC, Imfinzi + treme + TACE +/- lenvatinib EMERALD-3PD-L1+CTLA4+VEGF+/-chemo- embolization LR HCC, Imfinzi +/- tremelimumab + CRT ADRIATIC# PD-L1+/-CTLA-4+CRTLS-SCLC, monalizumab + cetuximab INTERLINK-1# NKG2A+EGFR 2L+ relapsed metastatic HNSCC, Lynparza + Imfinzi DUO-E# PARP+PD-L11L endometrial cancer, MET+PD-L1 1L papillary renal cell carcinoma. This is an excerpt of the original content. AstraZeneca has a long-standing commitment to making information about our clinical research publicly available. Please refer to your approved national product label (SmPC) for current product information. Veeva ID: Z4-46798Date of next review: August 2024. They randomized newly diagnosed metastatic men to either prostate radiation or. has received research grant support or served on . 2 Movement since Q4 2021 update Phase progressions based on first patient dose achievement. PCSK9 dyslipidemia. Clinical trials appendix H1 2022 results update Clinical trials appendix H1 2022 results update 2 Movement since Q1 2022 update Phase progressions based on first patient dose achievement. Additional indication. New to registration. For more information, please see - Disclosure Commitment. 10 - 12 phase Privacy Policy Phase III/LCM Projects: refers to assets that are pivotal in Phase II/III, or that have been submitted for regulatory approval, and may include assets that are now launched in one or more major markets (removed when launched in all applicable major markets). A Website where the public and trial participants can find published Trial Results Summaries for trials that started in late 2015 and beyond. AZD8853. Condition: Ovarian Cancer Intervention: Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Recruiting. AZD8853. discloses the following relationshipsAdvisory Board: AstraZeneca, Janssen-Cilag; Grant Support: Danish Cardiovascular Academy funded by the Novo Nordisk Foundation and the Danish Heart Foundation (grant number: CPD5Y-2022004-HF); Speaker Honorarium: AstraZeneca, Bayer, Boehringer Ingelheim, Janssen-Cilag.M.V. AstraZeneca PLC. Our investments in pioneering science give us confidence of further advances in the years to come., Adrian Kemp The goal is to stimulate the production .. AstraZeneca's Farxiga Improves Heart Failure Patients' Quality Of Life In Late-stage St.. ASTRAZENECA : Barclays reiterates its Buy rating, ASTRAZENECA : JP Morgan remains its Buy rating, Chief Executive Officer & Executive Director, Chief Financial Officer & Executive Director, EVP-Biopharmaceuticals Research & Development, Executive VP-Operations & Information Technology. AstraZeneca is not responsible for the privacy policy of any third party websites. ALXN1910 Next Gen TNSALP ERT Bone Metabolism; AZD0780 . Farxiga achieved $1bn revenue in the quarter and our Oncology medicines delivered Product Sales growth of 18%, despite COVID-19 continuing to impact cancer diagnosis and treatment. A Prespecified Secondary Analysis of the DELIVER Randomized Clinical Trial. and validation experiments on multiple cell lines and on clinical specimens. Legal Notice 1, 44, 45 results from the remaining 13 trials' main reports 3, 4, 7, 8, 9, 13, 17, 18, 20, 21, 30, Important notice for users You are about to access AstraZeneca historic archive material. This website is intended for people seeking information on AstraZeneca's worldwide business. Webcast replay Click here Downloads Announcement H1 2022 results announcement PDF 1,690KB Presentation H1 2022 results presentation PDF 5,465KB A AstraZeneca provides this link as a service to website visitors. 184 projects in our pipeline 17 GDF-15 solid tumours. here. Conflict of interest: M.P. PCSK9 dyslipidemia. Clinical trials appendix Full year and Q4 2020 results update Movement since Q3 2020 update . AstraZeneca Says FDA Advisory Committee Backs Approval of PT027 for Treatment of Asthma.. AstraZeneca celebrates asthma treatment recommendation by US FDA, ImpediMed Secures Contract Extension for Use of Device in Clinical Trial, AstraZeneca's Investigational Rescue Drug for Asthma Wins Backing from US FDA Panel, Beximco pharma warns on bangladesh covid revenues, IN BRIEF: Beximco Pharmaceuticals revenue up thanks to domestic sales. nextbot gmod . Our country sites can be located in the AZ Network. New to Pivotal trial. This was a post hoc analysis and conducted within a clinical trial setting among selected patients. I have read this warning and will not be using any of the contained product information for clinical purposes. Clinical trials appendix Q1 2022 2 Movement since Q4 2021 update Phase progressions based on first patient dose achievement. Main study and Biopsy sub-study: Duration of Response (DoR) [ Time Frame: Main study: 8 weeks after the start of treatment (Cycle 1 Day 1) until objective disease progression (approx 2 years); Biopsy study: 12 weeks after the start of treatment (Cycle 1 Day 1) until objective disease progression (approx 2 years) ] Our promise to post results, irrespective of whether they are favourable or unfavourable to AstraZeneca, remains unchanged. Additional indication. The airways in the lungs become narrow due to inflammation and tightening of the muscles around the small airways and also due to excess mucus. and Boehringer Ingelheim. You have selected a link that will take you to a site maintained by a third party who is solely responsible for its contents. Oral Factor D Inhibitor generalized myasthenia, AKT inhibitor + Docetaxel mCRPC prostate cancer, TROP-2 targeting antibody drug conjugate 1L TNBC. AZD8853. We encourage you to read the privacy policy of every website you visit. New to registration. Copyright 2022 Surperformance. AstraZeneca is not responsible for the privacy policy of any third party websites. This glossary will help you understand words and phrases frequently used on ClinicalTrials.gov. I have read this warning and will not be using any of the contained product information for clinical purposes. HER2 targeting antibody drug conjugate HER2-low, unresectable and/or metastatic breast cancer subjects, adjuvant EGFRm non-small cell lung cancer stage Ia2-Ia3. single family homes for sale in new castle county delaware eloghomes prices bethpage campground events . NME. Androgen deprivation therapy (ADT), which reduces levels of androgen hormones upon which prostate cancer relies, has been the mainstay of care for more than 60 years. Farxiga achieved $1bn revenue in the quarter and our Oncology medicines delivered Product Sales growth of 18%, despite COVID-19 continuing to impact cancer diagnosis and treatment. Our promise to post results, irrespective of whether they are favourable or unfavourable to AstraZeneca, remains unchanged. A New to registration. and Support for external requests for data sharing by allowing researchers to submit a request to access anonymized patient data via Vivli. AstraZeneca provides this link as a service to website visitors. Click cancel to return to AstraZenecas site or continue to proceed. NME. Whether the relationship between IGFBP-7 levels and outcomes would be similar in a broader population is unknown. Haematologica. Because we operate in an ever-changing environment, we monitor closely the developments and the advancements in this area to ensure we remain at the forefront of best practice in publicly sharing our clinical trial research. Please refer to your approved national product label (SmPC) for current product information. AZD8853. PCSK9 dyslipidemia. An accompanying webcast for investors and analysts took place at 11:45 UK time. Distributed by Public, unedited and unaltered, on 29 July 2022 06:23:06 UTC. Please refer to your approved national product label (SmPC) for current product information. 1 Submission accepted 2 Approved 3 Divested 4 Completed # Partnered and/or in collabora AstraZeneca Q1 2022 results Webcast for investors and analysts On Friday 29 April 2022 we announced our Q1 2022 results. Idelalisib was the first-in-class PI3K . New to Pivotal trial. ALXN1910 Next Gen TNSALP ERT Bone Metabolism; AZD0780 . You are about to access AstraZeneca historic archive material. 1Submission accepted 2Approved 3Divested 4Completed # Partnered and/or in collaboration Registrational Phase II/III trial New to Phase I New to Phase II New to Pivotal trial New to registration NME NI006# Important notice for users Phase progressions based on first patient dose achievement. Our country sites can be located in the AZ Network. The chart below shows the most common side effects among kids ages 5 to 11 in Pfizer 's clinical trial. 1Submission accepted 2Approved 3Divested 4Completed # Partnered and/or in collaboration Registrational Phase II/III trial New to Phase I New to Phase II New to Pivotal trial New to registration NME NI006# New to registration. NME. Our country sites can be located in the AZ Network. | November 2, 2022 Clinical trials appendix Q1 2022 2 Movement since Q4 2021 update Phase progressions based on first patient dose achievement. Important notice for users Precision medicine approach being explored, # Partnered and/or in collaboration; Registrational Phase II/III trial, Q2 2022 Oncology life-cycle management1 pipeline, Enhertu (platform) DESTINY-Breast08# HER2 ADC breast, Enhertu (platform) DESTINY-Breast07# HER2 ADC breast, Enhertu DESTINY-PanTumour01# HER2 targeting ADC HER2 mutant tumours, Calquence + R-CHOP ESCALADE BTK+R-CHOP 1L DLBCL, Enhertu DESTINY-Breast05# HER2 ADC breast, Calquence + venetoclax + obinutuzumab AMPLIFY# BTK + BCL-2 + anti-CD20 1L, Enhertu DESTINY-Breast06# HER2 ADC breast, Enhertu DESTINY-Breast04# HER2 ADC breast, Enhertu DESTINY-PanTumour02# HER2 targeting ADC HER2-expressing solid tumours, Imfinzi (platform) MAGELLAN# PD-L1 1L mNSCLC, Enhertu DESTINY-Breast09# HER2 ADC breast, Imfinzi + CRT PACIFIC-2#PD-L1+CRTlocally-advanced stage III NSCLC, PD-L1 mAb + CTx muscle invasive bladder cancer, Imfinzi + CRT PACIFIC-5 (China)# PD-L1+CRTlocally-advanced stage III NSCLC, Imfinzi + CTx neoadjuvant AEGEAN# PD-L1+CTxlocally-advanced stage II-III NSCLC, Imfinzi + domvanalimab (AB154) + CTx PACIFIC-8#PD-L1+TIGIT+CTx unresectable stage III NSCLC, 1 Includes significant life-cycle management projects and parallel indications for assets beyond Phase III, Imfinzi + FLOT MATTERHORN# PD-L1+CTxneo-adjuvant/adjuvant gastric cancer, Imfinzi POTOMAC PD-L1 mAb non-muscle invasive bladder cancer, EGFR inhibitor stage III EGFRm non- small cell lung cancer, Imfinzi + VEGF + TACE EMERALD-1#PD-L1+VEGF+TACE locoregional HCC, Tagrisso +/- CTx neoadjuvant NeoADAURA EGFR inhibitor +/- CTx stage II/III resectable EGFRm NSCLC, Tagrisso ADAURA2 EGFR inhibitor adjuvant EGFRm NSCLC stage Ia2-Ia3 following complete tumour resection, Q2 2022 BioPharmaceuticals new molecular entity1 pipeline, orexin 1 receptor antagonist opioid use disorder, FLAP coronary artery disease / CKD FLAP inhibition asthma, GLP-1/glucagon T2D / obesity / NASH / DKD, brazikumab EXPEDITION IL-23 mAb ulcerative colitis, NGF/TNF OA pain / painful diabetic neuropathy, 1 Includes novel combinations and additional indications for assets where the lead is not yet launched. 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