aspirin/citric acid/sodium bicarbonate will increase the level or effect of methotrexate by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)paclitaxel protein bound increases levels of doxorubicin by decreasing renal clearance. Do not exceed atorvastatin dose of 20 mg/day when coadministered with clarithromycinclarithromycin will increase the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Either increases toxicity of the other by Other (see comment). Minor/Significance Unknown. Surgery. Monitor closely. The above information is provided for general Minor/Significance Unknown. Avoid coadministration of lasmiditan with BCRP substrates. If coadministration unavoidable, separate administration by at least 6 hr before or after administration of P-gp substrates with narrow therapeutic index. Avoid or Use Alternate Drug. Coadministration with lomustine may increase the risk of immunosuppression and myelosuppression. This medication is removed by the kidneys. Avoid or Use Alternate Drug. Oncogene. Adjust finererone dosage as needed. Monitor Closely (1)atorvastatin will increase the level or effect of bazedoxifene/conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)sotorasib will decrease the level or effect of doxorubicin by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)valganciclovir increases toxicity of doxorubicin by pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. Conflicting evidence regarding this interaction exists. prednisone will decrease the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or substitute another drug for these medications when possible. Canada residents can call a provincial poison control center. Either increases toxicity of the other by pharmacodynamic synergism. Other (see comment). atorvastatin will increase the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter. Regorafenib likely inhibits BCRP (ABCG2) transport. Monitor Closely (2)doxorubicin decreases levels of phenytoin by increasing metabolism. Use Caution/Monitor. Serious - Use Alternative (1)sulindac increases levels of methotrexate by decreasing renal clearance. Take with a full glass of water. Comment: OATP1B1 inhibitors may increase risk of myopathy. Use Caution/Monitor. Modify Therapy/Monitor Closely. It belongs to a group of drugs known as "statins." Based on pharmacokinetic studies, atorvastatin Cmax decreased by 38% and median Tmax delayed from 1h to 3h and the AUC did not change. Other (see comment). Tablet, for solution; tablet, for suspension, Very soluble in water at pH < 5.5 (mesylate salt), -(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide. DVT/PE treatment: Decrease dose to 30 mg PO once daily. [, Croom KF, Perry CM: Imatinib mesylate: in the treatment of gastrointestinal stromal tumours. If this drug combination cannot be avoided, closely monitor for signs of hematologic toxicity. Serious - Use Alternative (1)flurbiprofen increases levels of methotrexate by decreasing renal clearance. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (1)methotrexate and rituximab-hyaluronidase both increase nephrotoxicity and/or ototoxicity. Monitor Closely (1)triclabendazole will increase the level or effect of pantoprazole by affecting hepatic enzyme CYP2C19 metabolism. Dosage adjustment of these BCRP substrates may be necessary. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid. Generic Name Famotidine DrugBank Accession Number DB00927 Background. Applies only to oral forms of hormone. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool.If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.A very serious allergic reaction to this drug is rare. Doxorubicin, in combination with other chemotherapies, may also slow the growth of children before puberty.This medication can affect fertility in males. Monitor Closely (1)ivacaftor increases levels of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)dicloxacillin increases levels of methotrexate by decreasing renal clearance. Clinical Pharmacy Prior Authorization, Notification and Medical Necessity Requirements - Commercial; Clinical Program Drug Step Therapy - Commercial Minor/Significance Unknown. If unavoidable, reduce CYP3A substrate dose according to product labeling. Use Caution/Monitor. 2006 Dec 3;551(1-3):27-33. Serious - Use Alternative (1)pantoprazole will increase the level or effect of talazoparib by Other (see comment). [, Adiwidjaja J, Boddy AV, McLachlan AJ: Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics. Monitor Closely (1)tucatinib will increase the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Applies only to oral form of both agents. pantoprazole decreases levels of acalabrutinib by increasing gastric pH. dosage, form, labeller, route of administration, and marketing period. Modify Therapy/Monitor Closely. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Share cases and questions with Physicians on Medscape consult. Use Caution/Monitor. tolmetin increases levels of methotrexate by decreasing renal clearance. NOTES: Do not share this medication with others.Laboratory and/or medical tests (such as a magnesium blood test), may be performed periodically to monitor your progress or check for side effects. Monitor closely. unknown mechanism. ferric maltol, methotrexate. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. Monitor Closely (1)atorvastatin will increase the level or effect of teniposide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)cidofovir and methotrexate both decrease immunosuppressive effects; risk of infection. Dosage adjustment is not needed. doxorubicin decreases levels of ethotoin by increasing metabolism. Use Caution/Monitor. It is a supplement used by people with low dietary intake Monitor Closely (2)acalabrutinib increases levels of methotrexate by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. bosentan will decrease the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanavir will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)methotrexate, zidovudine. pantoprazole decreases levels of rilpivirine by increasing gastric pH. Consider reducing dose when used concomitantly with lomitapide. pacritinib will increase the level or effect of methotrexate by Other (see comment). Monitor for toxicities of P-gp/BCRP substrate drug that may require dosage reduction when given concurrently with fostamatinib. [, Modi S, Seidman AD, Dickler M, Moasser M, D'Andrea G, Moynahan ME, Menell J, Panageas KS, Tan LK, Norton L, Hudis CA: A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer. Assess renal function, so appropriate methotrexate dose modifications can be made. Applies only to oral form of both agents. Use Caution/Monitor. Wait until Abx Tx complete to administer live bacterial vaccine. Minor/Significance Unknown. acalabrutinib increases levels of atorvastatin by Other (see comment). If possible, avoid coadministration or modify dose of OATP1B1/3 or BCRP substrates coadministered with fostemsavir. A: Generally acceptable. Monitor BCRP substrates for increased pharmacologic or adverse effects. [, Thomas J, Wang L, Clark RE, Pirmohamed M: Active transport of imatinib into and out of cells: implications for drug resistance. Monitor Closely (1)rufinamide will decrease the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Based on pharmacokinetic studies, atorvastatin Cmax decreased by 38% and median Tmax delayed from 1h to 3h and the AUC did not change. . This information is not individual medical advice and does not substitute for the advice of your health care professional. Monitor Closely (1)bosutinib increases levels of methotrexate by P-glycoprotein (MDR1) efflux transporter. MISSED DOSE: It is important to get each dose of this medication as scheduled. Applies only to oral form of both agents. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Closely monitor for signs and symptoms of increased exposure and consider adjusting the dose of these substrates. Use Caution/Monitor. A: Generally acceptable. Caution should be exercised when salicylates are given in combination with methotrexate. View the formulary and any restrictions for each plan. 3 This drug is an immunosuppressant combined with drugs such as Cyclosporine and corticosteroids to The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposurevalsartan increases toxicity of atorvastatin by Other (see comment). The cream and ointment are not effective for nail infections. oteseconazole. Monitor Closely (1)methotrexate decreases effects of tetanus toxoid adsorbed or fluid by pharmacodynamic antagonism. nefazodone will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Minor/Significance Unknown. Stiripentol is a CYP3A4 inhibitor and inducer. Use Caution/Monitor. Use Caution/Monitor. Serum level monitoring may facilitate tailoring dosage. Access now. Monitor Closely (1)lumefantrine will decrease the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. STORAGE: Store at room temperature away from light and moisture. This document does not contain all possible drug interactions. Serious - Use Alternative (1)diflunisal increases levels of methotrexate by decreasing renal clearance. Use Caution/Monitor. Access now. commonly, these are generic drugs. Antibiotics may decrease hormonal contraceptive efficacy. Use Caution/Monitor. Coadministration may increase systemic exposure of drugs that are BCRP substrates. Monitor Closely (1)aprepitant will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor for adverse reactions of OATP1B1 substrates when coadministered with voclosporin. Applies only to oral form of both agents. [. Modify Therapy/Monitor Closely. Copyright(c) 2022 First Databank, Inc. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. Monitor Closely (1)elagolix will increase the level or effect of methotrexate by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor Closely (2)elagolix will increase the level or effect of doxorubicin by P-glycoprotein (MDR1) efflux transporter. It will not work for viral infections (such as common cold, flu). Applies only to oral form of both agents. Minor/Significance Unknown. Monitor Closely (2)levoketoconazole will increase the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tafamidis inhibits breast cancer resistant protein (BCRP) in vitro and may increase exposure of BCRP substrates following tafamidis or tafamidis meglumine administration. doxorubicin will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. Individuals with altered immunocompetence may have reduced immune responses to the vaccine. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)methotrexate decreases effects of zoster vaccine recombinant by pharmacodynamic antagonism. Contraindicated. aluminum hydroxide decreases levels of nitrofurantoin by inhibition of GI absorption. Incidence and severity was highest when used with anthracycline-containing chemotherapy regimens. Contraindicated.Monitor Closely (1)pazopanib increases toxicity of atorvastatin by Other (see comment). Modify Therapy/Monitor Closely. 2020 Jan 30;10:1672. doi: 10.3389/fphar.2019.01672. tecovirimat will decrease the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Epub 2006 Sep 16. Patients vaccinated within a 14-day period before starting or during immunosuppressive therapy should be revaccinated =3 months after therapy is discontinued if immune competence has been restored. Take this medication with food to help minimize nausea. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. Use Caution/Monitor. 5 Food consumption has minimal effect on ezetimibe absorption, but the C max Comment: Close monitoring of cyclosporine and methotrexate concentrations, renal function, and liver enzymes is recommended during concurrent therapy. . oteseconazole will increase the level or effect of doxorubicin by Other (see comment). Monitor Closely (1)rucaparib will increase the level or effect of pantoprazole by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. 2014 Dec;39(6):685-90. doi: 10.1111/jcpt.12197. Minor/Significance Unknown. trastuzumab deruxtecan, doxorubicin. Your list will be saved and can be edited at any time. Build, train, & validate predictive machine-learning models with structured datasets. methotrexate decreases effects of influenza virus vaccine (H5N1), adjuvanted by Mechanism: pharmacodynamic antagonism. didanosine, nitrofurantoin. ropeginterferon alfa 2b, methotrexate. Modify Therapy/Monitor Closely. SIDE EFFECTS: Headache or diarrhea may occur. In fungi, lanosterol is then converted to ergosterol; in humans, lanosterol becomes cholesterol. atorvastatin will increase the level or effect of rimegepant by P-glycoprotein (MDR1) efflux transporter. If anthracyclines are used, carefully monitor cardiac function. secobarbital will decrease the level or effect of pantoprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Properly discard this product when it is expired or no longer needed. Avoid use of deferiprone with other drugs known to be associated with neutropenia or agranulocytosis; if an alternative is not possible, monitor absolute neutrophil count more frequently. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Monitor Closely (1)fosamprenavir will increase the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. Lonafarnib may increase the AUC and peak concentration of CYP2C19 substrates. Assess need to reduce dose of CYP2D6-metabolized drug. It may take up to 4 weeks before you get the full benefit of this drug. This drug is available at a higher level co-pay. Monitor Closely (1)methotrexate increases levels of theophylline by unknown mechanism. Monitor Closely (2)atorvastatin will increase the level or effect of tolvaptan by P-glycoprotein (MDR1) efflux transporter. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. Famotidine is a competitive histamine-2 (H 2) receptor antagonist that works to inhibit gastric acid secretion.It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs. Generic Name Imatinib DrugBank Accession Number DB00619 Background. Comment: Coadministration of daptomycin with HMG-CoA reductase inhibitors may increase CPK levels and risk for myopathy; consider temporary suspension of HMG-CoA reductase inhibitors during daptomycin therapy. You are being redirected to Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride[12][13][14] possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months). Avoid tanning booths and sunlamps. Use Caution/Monitor. . Consider a dose reduction of CYP2C19 substrates, as clinically appropriate, when used concomitantly with cenobamate. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Ask your doctor for more details.Tell your doctor if you are pregnant or plan to become pregnant. atorvastatin will increase the level or effect of irinotecan by P-glycoprotein (MDR1) efflux transporter. The LactMed database contains information on drugs and other chemicals to which breastfeeding mothers may be exposed. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Avoid or Use Alternate Drug. Fostemsavir inhibits BCRP transporters. Use Caution/Monitor. nifedipine will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Minor (1)magnesium chloride decreases levels of nitrofurantoin by inhibition of GI absorption. Carvedilol is a racemic mixture where the S(-) enantiomer is a beta adrenoceptor blocker and the R(+) enantiomer is both a beta and alpha-1 adrenoceptor blocker. . Use Caution/Monitor. Serious - Use Alternative (1)pantoprazole will increase the level or effect of alpelisib by Other (see comment). Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0.5 mg PO TID; monitor for signs of hypotension and reduce dose if needed. atorvastatin will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. nafcillin will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. US residents can call their local poison control center at 1-800-222-1222. Osimertinib is an inhibitor of BCRP transport. Limit atorvastatin dose to 20 mg/day. atorvastatin will increase the level or effect of dabigatran by P-glycoprotein (MDR1) efflux transporter. Other (see comment). Contraindicated. Use lowest starting dose of BCRP substrate, or consider reducing BCRP substrate dose. Serious - Use Alternative (1)diclofenac increases levels of methotrexate by decreasing renal clearance. verapamil will increase the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Applies only to oral form of both agents. Monitor methotrexate concentrations and adjust dose accordingly. Use Caution/Monitor. Acta Haematol. Modify Therapy/Monitor Closely. Limit atorvastatin dose to 20 mg/day. When switching from therapies with immune effects, take into account the duration and mechanism of action of these therapies when initiating ofatumumab SC. Monitor Closely (1)berotralstat will increase the level or effect of methotrexate by P-glycoprotein (MDR1) efflux transporter. Low risk of contraceptive failure. NSAIDs may reduce tubular secretion of methotrexate and enhance toxicity. Serious - Use Alternative (1)pacritinib will increase the level or effect of methotrexate by Other (see comment). Minor (1)magnesium hydroxide decreases levels of nitrofurantoin by inhibition of GI absorption. Use Caution/Monitor. Use Caution/Monitor. Vivjoa. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Minor/Significance Unknown. 2005 Jul;4(7):851-3. Biomed Res Int. This condition may occur during treatment or weeks to months after treatment has stopped. repaglinide increases toxicity of atorvastatin by Other (see comment). [, Hamada A, Miyano H, Watanabe H, Saito H: Interaction of imatinib mesilate with human P-glycoprotein. Comment: Concomitant use of proton pump inhibitors with erlotinib should be avoided if possible. Applies only to oral form of both agents. When possible, your doctor should switch you to the form that is taken by mouth. Use Caution/Monitor. Coadministration with ifosfamide may increase the risk of immunosuppression and myelosuppression. Monitor Closely (1)nevirapine will decrease the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This drug is available at the lowest co-pay. Other (see comment). Avoid or Use Alternate Drug. Monitor Closely (1)posaconazole will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. itraconazole will increase the level or effect of doxorubicin by Other (see comment). oxcarbazepine commonly, these are "non-preferred" brand drugs. Use Caution/Monitor. Use Caution/Monitor. Take your next dose at the regular time. Access now. Inform your doctor if you notice signs of a new urinary tract infection (such as pain while you are urinating).If you are taking this medication to treat an infection, continue to take this medication until the full-prescribed amount is finished, even if symptoms disappear after a few days. Use Caution/Monitor. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. Compare formulary status to other drugs in the same class. Use Caution/Monitor. Monitor Closely (1)doxorubicin increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Blood.
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