Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines with the potential to deliver transformative value for patients. Currently, there are no approved treatments for GAN, which results in death for patients in their late teens or early twenties. By using this site, you accept our use of cookies as described in our privacy policy. Any information on the products contained herein is not intended to provide medical advice nor should be used as a substitute for the advice provided by your physician or other healthcare provider. TOKYO and SANFORD, N.C., June 8, 2022 /PRNewswire/ --Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas") today announced the opening of a new late-stage clinical and commercial manufacturing facility in Sanford, N.C. This role will develop insights for Astellas Gene Therapies (AGT) including tracking the gene therapy landscape to understand how our assets are differentiated, assessing the commercial potential of new opportunities (BD and/or new R&D opportunities), and building market knowledge and identifying actionable insights to support product . Under the terms of the agreement, Astellas will invest a total of $50 million to acquire 15 percent of the outstanding The website you are about to visit is not owned or controlled by Astellas. TSHA-102 has received Orphan Drug and Rare Pediatric Disease designations from the U.S. Food and Drug Administration (FDA) and Orphan Drug Designation from the European Commission. Your submission may be shared on the Astellas Gene Therapies website, and we will share your experiences with our employees, including the Audentes folks designing and helping run clinical trials to help inspire their work. If you have any questions or would like to opt-out from use of your information and/or photo,please contact: AGT_PatientAdvocacy@astellas.com, Your input makes all the difference. Please read our privacy policy for more information on the cookies we use, the processing of your personal data and how to delete or block the use of cookies. The new facility located at 6074 Enterprise Park Drive joins the vibrant biopharmaceutical research and manufacturing community established in Lee County. Astellas said it ultimately invested $100 million in the facility, where it expects to create more than 200 jobs by the end of 2026. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug including those under development. Astellas Gene Therapies is based in San Francisco, with manufacturing and laboratory facilities in South San Francisco, Calif., and Sanford, N.C. Astellas Cautionary NotesIn this press release, statements made with respect to current plans, estimates, strategies and beliefs and other statements that are not historical facts are forward-looking statements about the future performance of Astellas. Forward-Looking Statements (Taysha)This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. It only takes a second, and your review is anonymous. For more information, please visit our website athttps://www.astellas.com/en. This office is the major Astellas Gene Therapies Sanford, NC area location. Astellas and Taysha Gene Therapies Announce Strategic Investment to Support Development of Taysha's AAV-based Gene Therapy Programs. Astellas Unveils Plans to Open New Biotech Campus in South San Francisco, For further information: Astellas Portfolio Communications, Cassie Hogenkamp, +1-847-942-0980, cassie.hogenkamp@astellas.com; Astellas Pharma Inc., Corporate Advocacy & Relations, +81-3-3244-3201, California Declaration of Comprehensive Compliance Program, Vermonts Pharmaceutical Marketer Price Disclosure, Wholesale Acquisition Cost Information for Colorado Prescribers, Consumer Product Safety Commission Regulations, Understanding the Gastric and GEJ Cancer Landscape. The latest investment gives Astellas a larger presence in gene therapy, an area it's invested heavily in since 2019, when it bought Audentes Therapeutics for $3 billion. Preliminary data from Astellas Pharma's gene therapy study in adult patients with Pompe disease has crossed a first safety hurdle. With the establishment of the Astellas Gene Therapies Center of Excellence following the 2020 acquisition of Audentes Therapeutics Inc., Astellas is a leader in genetic medicines, working alongside its world-renowned partners to build a portfolio of potentially life-changing gene therapies. "Similar to the Astellas Biomedical Innovation Hub located in the greater Boston area, this new facility will foster even greater levels of collaboration amongst our world-class, multi-disciplinary teams working in cell and gene therapies, development of business opportunities and all those who support our endeavors to create value for patients.". Our communications team will respond to verified media requests within 24-48 hours as appropriate. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug including those under development. "Taysha is an industry leader in CNS gene therapies and this partnership fits strategically with our long-term vision of expanding Astellas' gene therapy capabilities, allowing the company to impact the lives of a broader range of patients with urgent unmet medical needs. A number of factors could cause actual results to differ materially from those discussed in the forward-looking statements. Your experience as a person or family member living with a rare condition inspires our work. Astellas Gene Therapies (AGT) is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. This website is intended for U.S. residents only. Astellas Gene Therapies Salaries by Location. Definitive agreements would be executed upon Astellas' exercise of any such option, and any change of control transaction would require approval by Taysha's stockholders. Our mission at Astellas, through Primary Focus Genetic Regulation and Astellas Gene Therapies, our Gene Therapy Centre of Excellence, is to discover, develop and deliver meaningful gene-based therapies for patients with genetic diseases. Please click here for a complete list of our global locations Astellas Gene Therapies San Francisco, California 1-415-818-1005 https://www.audentestx.com/ Astellas Pharma US, Inc. Astellas US Headquarters Northbrook, Illinois 1-800-888-7704 Astellas Pharma Global Development, Inc. Northbrook, Illinois 1-800-888-7704 It only takes a second, and your information is anonymous. With recent advances in science, cell therapy is on the verge of becoming a reality for these unmet medical needs. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. Taysha is engaged in the development of intrathecally-delivered AAV gene therapies for monogenic CNS diseases. Astellas Gene Therapies is a biotechnology company developing new genetic medicines for rare, life-threatening diseases. Our communications team will respond to verified media requests within 24-48 hours as appropriate. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. TSHA-102 utilizes the novel miRNA-Responsive Auto-Regulatory Element (miRARE) platform to regulate transgene expression genotypically on a cell-by-cell basis. Primarily occurring in females, Rett syndrome is one of the most common genetic causes of severe intellectual disability worldwide. Pompe Disease (Late-onset) Genetic: AT845. Astellas Celebrates the Opening of Its New Large-Scale Gene Therapy Manufacturing Facility in North Carolina - 135,000 square-foot state-of-the-art gene therapy manufacturing facility located in Sanford, N.C., officially opened June 8 About Astellas Gene TherapiesAstellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines with the potential to deliver transformative value for patients. By combining our ACCEL technology, a universal CAR (chimeric antigen receptor), and Universal Cells' Universal Donor Cells (UDC) technology, we aim to create a unique platform that offers greater speed and flexibility compared to currently approved chimeric antigen receptor cell therapies and expands potential value for as many cancer patients as possible. Plans for the 135,000-square-foot facility were initially unveiled in early 2020 by Audentes Therapeutics, a gene therapy developer that Astellas had just acquired for $3 billion. For media inquiries and reporter requests, please click here to fill out a request form. He has more than 25 years of experience in the research, development, and commercialization About TSHA-120TSHA-120, an intrathecally dosed AAV9 gene replacement therapy delivering the gene gigaxonin for the treatment of GAN, is currently being evaluated in an ongoing Phase 1/2 clinical trial. Under this vision, Astellas is focused on bringing life-changing cell and gene therapy treatments to patients suffering from diseases that lack treatment options. The new innovation and research center will include employees across research, technical operations, medical and development, commercial, and relevant administrative support functions. Get to Know Us We want to provide What matters to you. Forward-looking statements are based on management's current expectations and are subject to various risks and uncertainties that could cause actual results to differ materially and adversely from those expressed or implied by such forward-looking statements. Any information on the products contained herein is not intended to provide medical advice nor should be used as a substitute for the advice provided by your physician or other healthcare provider. Browse jobs and read about the Astellas Gene Therapies Sanford location with content posted anonymously by Astellas Gene Therapies employees in Sanford, NC. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. More information is available atwww.tayshagtx.com. This role will help implement and monitor the routine systems, procedures, and records to support GMP-compliant manufacturing, and batch review and release of Astellas Gene Therapy biological products. The website you are about to visit is not owned or controlled by Astellas. Interview Questions. Regional headquarters (Astellas EMEA operations) Astellas Pharma Europe Ltd. R&D and manufacturing bases Astellas Pharma Europe B.V. (Netherlands) Astellas Ireland Co., Limited (Ireland) Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice. Salaries posted anonymously by Astellas Gene Therapies employees. Get this page going by posting your interview experience. Astellas Celebrates the Opening of Its New Large-Scale Gene Therapy Manufacturing Facility in North Carolina, Astellas-Gene-Therapies-Manufacturing-Facility, For further information: Astellas Portfolio Communications, Cassie Hogenkamp, +1-847-942-0980, cassie.hogenkamp@astellas.com; Astellas Pharma Inc., Corporate Advocacy & Relations, +81-3-3244-3201, California Declaration of Comprehensive Compliance Program, Vermonts Pharmaceutical Marketer Price Disclosure, Wholesale Acquisition Cost Information for Colorado Prescribers, Consumer Product Safety Commission Regulations, Understanding the Gastric and GEJ Cancer Landscape. For further information: Contacts for inquiries or additional information: Astellas Pharma Inc., Corporate Advocacy & Relations, TEL: +81-3-3244-3201; Dyno Therapeutics, Nisha Deo, Head of Communications, TEL: +1-857-242-0593 The Sanford facility enables continual learning and efficient knowledge-sharing, helping to improve the pace and effectiveness of drug development. Matt Patterson is the co-founder of Audentes Therapeutics and has served as Chief Executive Officer since the company's inception in November 2012. Audentes Therapeutics A little bit about us: Our goal is to deliver meaningful gene therapy clinical development programs, educational materials, and resources to support the rare disease community. Compare Astellas Gene Therapies office locations by office rating, and see reviews, jobs, salaries & interviews from Astellas Gene Therapies employees in each office location. HR phone interview --> hiring manager phone interview --> onsite (multiple one on one, a group lunch, last around 3-4 hr). At WORLDSymposium, Astellas presented interim safety data from a Phase I/II study assessing its AAV gene therapy for the rare, autosomal metabolic disease.. Weston Miller, M.D., senior medical director of clinical development at . . The acquisition added an additional Primary Focus Area, Genetic Regulation, to Astella's three primary areas: Blindness & Regeneration; Mitochondria Biology; and Immuno-Oncology. A free inside look at Astellas Gene Therapies salary trends based on 89 salaries wages for 56 jobs at Astellas Gene Therapies. Astellas Institute for Regenerative Medicine. This website contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, or in different dosages. Under the terms of the agreement, Astellas will invest a total of $50 million to acquire 15% of the outstanding common stock of Taysha and to receive an exclusive option to license two of Taysha's clinical stage programs: TSHA-102 for Rett syndrome and TSHA-120 forGAN. The future options to potentially apply Astellas' global R&D, manufacturing and commercialization capabilities in gene therapy to Taysha's innovative AAV gene therapy development programs for genetic diseases of the central nervous system (CNS) create the opportunity for the two companies to enhance the development of novel treatment options for patients with Rett syndrome and GAN, who have serious unmet medical needs. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. "Our new manufacturing facility symbolizes our company's continued dedication to the advancement of novel life-changing gene therapies for patients with severe diseases and a significant unmet need, as well as our commitment to the Sanford community," said Mathew Pletcher, Ph.D., Senior Vice President and Division Head of Gene Therapy Research and Technical Operations at Astellas Gene Therapies. This website provides access to information from Astellas sponsored clinical trials and the purpose is not to promote or advertise any Read about our latest progress around our Corporate Strategic Plan. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug including those under development. The facility will allow the company to expand its resources and team to establish a robust, global supply chain and expand its therapeutic and geographic scope. In addition, the co-location of these businesses allows for more efficient use of space by combining the lab and office facilities into one new building, compared to current independent locations. This website provides access to information from Astellas sponsored clinical trials and the purpose is not to promote or advertise any Read about our latest progress around our Corporate Strategic Plan. Copyright 2008-2022, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco, Calif., and Sanford, N.C. About Xyphos Biosciences, Inc., an Astellas CompanyXyphos Biosciences Inc., located in South San Francisco, Calif., is an Astellas Center of Excellence for Cancer Cell Therapy developing medicines to cure solid tumors with a precision, off-the-shelf "Standard Pharmaceutical like Cell Therapy" platform, which can be easily tailored to the needs of individual patients and adapted to multiple disease targets. About AstellasAstellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. The miRARE technology is designed to prevent toxicity associated with transgene overexpression and can be potentially utilized across other indications. Up to 3 nominal dose levels of AT845 . Astellas will be the sole occupant of the new building and will spend the next year equipping the interior with state-of-the-art research labs, office spaces, and other amenities specifically designed to accommodate the West Coast employees of Astellas Gene Therapies, Xyphos Biosciences, business development, Rx+ Business Accelerator, and the planned future growth within those units. Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. Sorry, you need to enable JavaScript to visit this website. "By uniting our business units in the Bay Area, we are creating a dedicated West Coast center in the vibrant South San Francisco corridor alongside other leaders in the biotechnology and pharmaceutical industry," said Yoshitsugu Shitaka, Ph.D., Chief Scientific Officer at Astellas. The new 154,000-square-foot building at 480 Forbes Boulevard will allow for the co-location of several Astellas business units and functions currently located independently throughout the San Francisco area. We are working urgently to progress our medicines and need additional team . By using this site, you accept our use of cookies as described in our privacy policy. For media inquiries and reporter requests, please click here to fill out a request form. "We run very similar manufacturing platforms," Alam said. "Our state's skilled workforce, leading academic institutions and healthy business environment provide all the resources they need to foster innovation and continued success.". Tell us about one of your day-to-day activities and how your experience might be a little different as a patient Astellas expects to complete the building and be operational in summer 2023. 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