We're seeing that mix shift in our duration increase over time. And so we'll be providing updated guidance as we get a better sense of when those events might come in for OS. Available to answer your questions after our prepared remarks are Dick Lavey, President of Agency Markets; and Bryan Salvatore, President of Specialty Lines. If you have an ad-blocker enabled you may be blocked from proceeding. They are having a good October and still focused more on the U.S. Were still collecting data here for Europe. Yeah, so there was data presented on the five consecutive days every three weeks, and then three consecutive days every three weeks. Theres still attrition in our business, along with everybody elses, but were pretty much at 95% full strength and have been for this quarter. So with respect to the overall survival from COSMIC-313 and just sort of a quick reminder on the study design here. So I would say stay tuned there as far as where we'll land on the dose. If anyone should require Operator assistance during the conference, please press star, zero on your telephone keypad. It was very broad based and diverse. Media. Quarterly Earnings. We continue to expand the capabilities of our ProteinSimple line of instruments in cell and gene therapy applications. Can you talk about what we should be looking for in the STELLAR-002 data at SITC as you build on the expectations that were set with the initial STELLAR-001 data you presented at ESMO? Thanks. Was there another question? I would like to turn the conference back over to Oksana Lukasheva for any closing remarks. If that doesnt develop, there might be a bit of a headwind, but in general North America is steady-eddy. It seems from the activity that's been heightened on the business development front, and as you outline in the opening sentence of the press release for the quarter, that you have a focus on things that are sort of clinical or near to clinical. And do you prioritize potential deals by a certain novel drug technology or looking at clinically validated targets? Bob, thank goodness you got in. Even Asuragen, growing near 25%, lighting it up in Europe, needing people, were adding people. Great. That's really helpful color. From a fixed income portfolio valuation perspective, this was a particularly impactful quarter due to the sharp increase in rates. Do you exclude that potential sales to clinical trials? mentioned, in September, we ended September in a very strong fashion from a demand and new patients perspective. I think I somewhat agree with your characterization. We've seen that in other years and it's right now we're not providing guidance or recommendations for 2023 yet, but we'll -- we could talk about that on the Q4 call in February. In accordance with the GRI guidelines, we conduct a materiality assessment on key topics that are highly relevant to us and our key stakeholders. Was it XB002, I'm not sure for the asset directly. Good afternoon. Yeah, with respect to Cybrexa, the way it's structured, right, that's an upfront payment. Ladies and gentlemen, this concludes todays conference call. But I would tell you, net-net, because workers' comp is based on payrolls, you are able to keep up with that quite easily as long as you are auditing the accounts properly. Its still sporadic; in fact, weve got meetings this week where I was trying to get my head of Asia in. I'll then provide a strategic review of each of our business segments; Jeff will review our financial results in more detail; and then we'll open up the line and take your questions. With that said our investment portfolio remains very well positioned. We havent discussed TcBuster for a while, so I will update you on the significant progress we are experiencing with our non-viral gene editing technology. And as we built out and are building out those portals, we actually attach them to that TAP sales capability that we built in small, so that our agents have that one experience as they're looking to place multiple lines. How that's going to play out clinically? Next, Ill discuss the performance of our reporting segments, starting with the protein sciences segment. I mean, you guys obviously placed a ton of those systems during COVID, so when it just comes to this overall comp issue that were talking about here, Im curious how you think utilization and recurring revenue streams compare as we come off the peak. Thanks. These data were presented by Dr. Toni Choueiri in a presidential symposium at ESMO. We also continue to evaluate additional potential combination opportunities with novel agents. Foreign exchange translation had an unfavorable impact of 3% and acquisitions had a favorable impact of 1% to revenue growth. Please see Slide 12 of our Q3 earnings presentation for further details. Some of the inflation severity impact in Q1 versus the prior year quarter may be less noticeable because of elevated large fire and non-CAT weather losses in Q1 2021. Third, business development activities continue to be a critical focus for Exelixis. You mentioned that you have seen the highest levels of new patient starts versus what is available in public sources. The decrease was primarily driven by unfavorable foreign exchange impact partially offset by productivity gains. Or is this something that could have a broader potential without selection in breast cancer? Contact Locations. I am curious if there is a way to either through a biomarker or potentially F-18 FDG to really select for patients who might best benefit from this kind of therapy. A reconciliation of these non-GAAP financial measures to the closest GAAP measure on a historical basis can be found in the press release, the slide presentation, or the financial supplement, which are posted on our website, as I mentioned earlier. We will be looking at mature PFS data and interim for OS, and essentially the trial needs to hit one of the endpoints to be declared a successful trial. And you'd expand that to go through 2023 as well, it's not a kind of a when [inaudible]. And so, we continue to work very closely with our field folks. We continue to educate the market on the advantages of TcBuster, and its worth noting that we have signed a handful of commercial licenses to support a growing pipeline of cell therapies, primarily for T-cell and NK cell therapies. Yeah, Peter, thanks. ET, Here's Why This Growth Stock Is Already My 2022 Winner, Worried About Rising Interest Rates? In the first quarter, we continued to build on our leading position in the small to midsized Specialty segment. Good morning and welcome to the Bio-Techne earnings conference call for the first quarter of fiscal year 2023. During the quarter, we replaced our previous debt financing with a new $1 billion line of credit facility with a five-year term. We see China rapidly returning to its historical growth rates as prior year comps normalize, customers continue to better navigate the sporadic COVID-related government restrictions, and the Chinese government continues to emphasize investing in healthcare. You may disconnect your lines at this time. Calculated by Time-Weighted Return since 2002. And we are seeing the dynamic of a competitive employment market, driving up payrolls. And then just one other question. Hey, guys. Is it share gains from what -- is it still moving away from the old TKIs or is it potentially continuing to make dent into the nivo ipi opportunity? Account business in total now represents 87% of our Personal Lines book. And then second, the early data for CBX-12 was pretty interesting at ENA, interesting technology as well in terms of this pH dependency. Was it Europe kind of coming back? Now lets shift to the diagnostics and genomics segment, where we grew revenue by 17% organically in the quarter. Hi, good morning guys. As you pointed out, I'd maybe just highlight three things in the quarter in terms of its strength. The 10-K as well as the companys other SEC filings are available on the companys website within its Investor Relations section. This includes statements about possible developments regarding discovery, product development, regulatory, commercial, financial and strategic matters. We are leveraging our sophisticated data and analytics, which provide detailed insight into the latest assessment of trends, allowing us to react nimbly and quickly to changes in the market. Oct. 18, 2022 11:00 AM ET Roche Holding AG (RHHBY), RHHBF, RHHVF. Important clinical updates for XL092 at EORTC and XB002 at ENA highlight recent progress to lay the foundation from moving these compounds into late-stage development. I think I said double digit to mid teens, maybe there was a high teen or two. As we talked about earlier, too, we've seen gross net come down quarter to quarter from Q1 to Q3. We have the ability to take the asset on. Silvan Turkcan -- JMP Securities -- Analyst. Our view is we have to do deals with and four assets that we have conviction can actually work, and then we get to a point where in the case of both assets, we can move forward pretty aggressively once we have proof of concept data. Good morning, and welcome to the Hanover Insurance First Quarter 2022 Earnings Conference Call. We have not enough whales, a few tunas, and way too many plankton in our customer list, so weve got 150 customers that only a handful are really large ones, and obviously the theres a timing issue, theyre spotty in their orders for their clinicals and such. Fractionation is a front-end step in mass spectrometry where the sample to be analyzed is separated into mixture components based on differences in their size, charge, or other characteristics. I will dig into the traction and encouraging trends we are seeing across the segment in our broader portfolio later in the call. Our spatial biology business, branded ACD, accelerated to upper teens growth in the quarter as strong commercial execution and an enhanced marketing strategy generated well-balanced growth in both our bio-pharma and academic end markets. So that's up to the trial and their ordering patterns. Our positive trajectory demonstrates the quality of our portfolio, as well as the robust strength of our enviable agency partnerships. Since normal tissues have low or no expression of the selected target, they do not take up the payload, minimizing side effects. So I mean, the ADC looked pretty safe. In our first quarter, we accelerated our spatial biology business to upper teens growth. Just curious about how you think about it from a product development standpoint. Today's discussion will also reference certain non-GAAP financial measures such as operating income and accident year loss and combined ratios, excluding catastrophes among others. Susan Hubbard -- Executive Vice President of Public Affairs and Investor Relations. Past Media events View more Events. You heard the news from Jim there - were more concerned about that, were more concerned about our long term outlook, which we dont think has changed a bit, and thats some highlights there. Downloads. We are aligning our pricing in recognition of these higher exposures. Turning to the TKI market basket of CABOMETYX, INLYTA, SUTENT, VOTRIENT and Lenvima. Thank you. Thanks. We got everything we wanted back to match the NCCN guidelines about one issue, and thats the negative biopsy, so were really good to go and that more or less doubles the TAM. All participants will be in listen-only mode. Just wondering if you could help set expectations for the scope of this update here at San Antonio. Im more concerned about losing great people and getting behind all this attrition. Were changing our message to lining up with Cal Ripken Jr. again, a lot of shows, but we are just ready to publish the next--the 2.5 year outcome study, which is like 1,000 patients. TcBuster is currently being trialed in dozens of unique therapies, and we believe the future is very bright for this technology. Hey, guys. We provide integrated information about Roches financial and non-financial performance in our Annual Report , Finance Report as well as in our online report , and cover all regions and divisions from 1 January to 31 December 2021. DBS INVESTOR PRESENTATION EMAIL ALERTS. In addition to the ongoing geographic expansion, Asuragen has a rich product pipeline positioning the business for continued growth going forward. In particular, the P&C industry has various effective tools at its disposal to help offset the pressure, including rate and exposure increases and it certainly benefits meaningfully from the higher interest rates over time. They are helping more out, the whole scale ready team, from a proteins point of view because were going to be adding more and more proteins to our factory. Well let you dig in deeper now. Within the development organization, key hires include three executive-level leaders who are based at King of Prussia, and we've seen an uptick in East Coast-based candidate awareness and enthusiasm for the new site. Yaron Werber -- Cowen and Company -- Analyst. Ill just add, Chuck, were hearing from our commercial teams, its not so much--its not that were losing any kind of bulk orders or instrument orders, its more about delay in getting them through the system. Before I turn the call over to Jack, let me note that our earnings press release, financial supplement and a complete slide presentation for today's call are available in the Investors section of our website at www.hanover.com. Thanks, Mike. We continue to penetrate the burgeoning cell therapy opportunity with our portfolio of GMP proteins and are seeing continued momentum in the regenerative medicine, or regen med market. As stated in the fourth quarter fiscal year 22 earnings call, we expect Q1 to be the low point for adjusted operating margins for the year. At the same time, approximately 25% of our customers now have an umbrella coverage, one of the most profitable coverages in Personal Lines, and this number continues to climb. Yeah, we are really pleased with the quarter. The only thing we didnt cover too much, but more good news there. Michael Schmidt -- Guggenheim Partners -- Analyst. Please go ahead. So it won't go too far. Thank you for attending today's presentation. We talked about the steady improvement in China and were on track, if not better than on track for this quarter and beyond. That's right -- theythink these 10stocks are even better buys. We expect to see a sizable lift from fixed maturity net investment income in 2022 and an even more meaningful increase in 2023 and beyond. It is important to note that there are 10 SIRPalpha alleles in humans with their frequencies varying by population, and antibodies vary in their ability to bind the different alleles. Etzer Darout -- BMO Capital Markets -- Analyst. This decrease in gross to net deductions in the third quarter 2022 is primarily related to lower PHS, Medicare Part D and co-pay assistance. Decreased to 79.58 or 10.2 % from December 31, 2021 we delivered 97.1. Other companies that are key components in the broader insurance and economic environment and how that evolve Top-Line growth of 9.4 %, propelled by stable rate increases in Specialty and strong share. And cookies in your browser deliberately and profitably grow our business of navigating. Or $ 0.31 per share, which decreased to 79.58 or 10.2 % 90! The robust strength of our shareholders ' capital Standards in 2017 morning are Chuck Kummeth, Chief financial.! 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